Parker Gordon, Brotchie Heather, Fletcher Kathryn, Hyett Matthew, Barrett Melissa
School of Psychiatry, University of New South Wales, Black Dog Institute, Sydney, NSW, Australia.
Australas Psychiatry. 2007 Apr;15(2):125-9. doi: 10.1080/10398560701196737.
The aim of this study was to determine whether short-term outcome for those referred with a depressive disorder could be predicted from baseline clinical assessment and identify factors contributing to outcome in a clinic operating to a subtyping diagnostic and aetiologically weighted management model.
This pilot study involved a consecutive series of 85 patients referred to the Depression Clinic at the Black Dog Institute.
Globally assessed baseline prediction was associated with short-term outcome. Comparably high rates of improvement were evident in those with bipolar, melancholic and non-melancholic subtypes, and somewhat lower in those diagnosed with a 'secondary depression'. Qualitative and quantitative analyses established that outcome was most clearly associated with referral source, degree of take up of recommendations and implementation of psychotropic drug strategies.
Study results encourage more definitive and comparative study designs to be derived.
本研究旨在确定能否通过基线临床评估预测抑郁症转诊患者的短期预后，并在采用亚型诊断和病因加权管理模式的诊所中识别影响预后的因素。
这项试点研究纳入了连续转诊至黑狗研究所抑郁症诊所的85例患者。
整体评估的基线预测与短期预后相关。双相、 melancholic和非melancholic亚型患者的改善率相当高，而诊断为“继发性抑郁症”的患者改善率略低。定性和定量分析表明，预后与转诊来源、建议采纳程度和精神药物治疗策略的实施最为密切相关。
研究结果促使开展更具确定性和对比性的研究设计。
