Miller Jamie Leigh, Ericson Solveig Gronning
Department of Microbiology/Immunology/Cell Biology, and Blood and Marrow Transplant and Hematologic Malignancy Program of Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, USA.
Immunopharmacol Immunotoxicol. 2007;29(1):105-18. doi: 10.1080/08923970701282890.
Cyclosporin A (CSA) and tacrolimus (FK506) are two common immunosuppressive agents used post blood and marrow transplantation. Despite similarity in their accepted modes of action, we observed polarized effects of CSA and FK506 on the in vivo human T cell repertoire. To determine the possible mechanism for this difference, the effects of CSA and FK506 on cell viability, cell proliferation, interleukin-2 production, and calcineurin inhibition were determined in vitro. Our data suggest that a secondary mechanism of action exists for the different T-cell repertoire induced by exposure to CSA and FK506.
环孢素A（CSA）和他克莫司（FK506）是血液和骨髓移植后常用的两种免疫抑制剂。尽管它们公认的作用方式相似，但我们观察到CSA和FK506对体内人类T细胞库有极化效应。为了确定这种差异的可能机制，我们在体外测定了CSA和FK506对细胞活力、细胞增殖、白细胞介素-2产生和钙调神经磷酸酶抑制的影响。我们的数据表明，暴露于CSA和FK506所诱导的不同T细胞库存在第二种作用机制。
