Sun Bao-Liang, Yuan Hui, Yang Ming-Feng, Xia Zuo-Li, Zhang Su-Ming, Wang Le-Xin
Department of Neurology & Institute of Microcirculation Affiliated Hospital, Taishan Medical College, Shandong, China.
Int J Neurosci. 2007 May;117(5):655-65. doi: 10.1080/00207450600773871.
The purpose of this study was to investigate in effect of extract of Ginkgo biloba (EGb) on cerebral blood perfusion in a subarachnoid haemorrhage (SAH) rat model. SAH lead to an increase in intracranial pressure and decrease in cranial perfusion pressure and regional cerebral blood flow in all groups. However, the intracranial pressure increases in EGb groups were less than that of the vehicle group (p < .01), whereas the reduction in cranial perfusion pressure and regional cerebral blood flow in the EGb group was less than that of the vehicle and SAH groups (p < .01). It was concluded that EGb attenuates the increase in intracranial pressure and reduction in cerebral blood perfusion after SAH.
本研究的目的是探讨银杏叶提取物（EGb）对蛛网膜下腔出血（SAH）大鼠模型脑血流灌注的影响。SAH导致所有组的颅内压升高、颅灌注压降低和局部脑血流量减少。然而，EGb组的颅内压升高幅度小于载体组（p <.01），而EGb组的颅灌注压和局部脑血流量降低幅度小于载体组和SAH组（p <.01）。得出的结论是，EGb可减轻SAH后颅内压的升高和脑血流灌注的降低。
