Sun B L, Xia Z L, Yang M F, Qiu P M
Department of Neurology, Affiliated Hospital of Taishan Medical College, Taian 271000, Shandong, China.
Zhongguo Zhong Yao Za Zhi. 2001 May;26(5):329-32.
To observe the changes of somatosensory evoked potential(SEP) and nitric oxide (NO) after subarachnoid hemorrhage(SAH), and the influence of Ginkgo biloba extract (EGb).
Rats in sham-operated group, SAH model group and EGb-treated group underwent measurement of dynamic changes of regional cerebral blood flow(rCBF), SEP and NO levels both in serum and in brain tissue within 24 h after operation.
In SAH group, rCBF decreased immediately after operation, with no tendency to recover within 24 h. The latency of SEP delayed progressively from 1 h to 24 h after SAH. NO levels in serum and in brain tissue decreased and increased respectively from 1 h to 24 h after SAH. EGb effectively antagonized the changes of above parameters.
SEP is helpful in the judgement on brain ischemic damage after SAH. Decrease of NO in serum and increase of that in brain tissue may lead to cerebral vasospasm and ischemic brain damage respectively after SAH. EGb relieves SAH-induced brain ischemic damage by reversing the pathological alterations of NO.
观察蛛网膜下腔出血（SAH）后体感诱发电位（SEP）及一氧化氮（NO）的变化，以及银杏叶提取物（EGb）的影响。
将大鼠分为假手术组、SAH模型组和EGb治疗组，于术后24小时内测定局部脑血流量（rCBF）、SEP以及血清和脑组织中NO水平的动态变化。
SAH组术后rCBF立即下降，24小时内无恢复趋势。SAH后1小时至24小时，SEP潜伏期逐渐延长。SAH后1小时至24小时，血清和脑组织中NO水平分别降低和升高。EGb有效对抗了上述参数的变化。
SEP有助于判断SAH后脑缺血损伤。SAH后血清中NO降低和脑组织中NO升高可能分别导致脑血管痉挛和脑缺血损伤。EGb通过逆转NO的病理改变减轻SAH所致的脑缺血损伤。
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