Kroenke Mark A, Segal Benjamin M
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
J Neurosci Res. 2007 Jun;85(8):1685-93. doi: 10.1002/jnr.21291.
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to multiple sclerosis (MS). It has been suggested that relapses of EAE and MS may be associated with, and even driven by, T cells specific for novel epitopes that are primed during the course of tissue destruction in the target organ or in secondary lymphoid tissues. We show, however, that IFNgamma and IL-17 responses against the immunizing epitope remain dominant through out the course of multiphasic EAE. Furthermore, induction of tolerance against a putative secondary epitope did not prevent clinical relapses.
实验性自身免疫性脑脊髓炎（EAE）是一种与多发性硬化症（MS）相似的炎性脱髓鞘疾病。有人提出，EAE和MS的复发可能与在靶器官或二级淋巴组织的组织破坏过程中引发的针对新表位的T细胞有关，甚至由其驱动。然而，我们发现，在多相性EAE的整个病程中，针对免疫表位的IFNγ和IL-17反应仍然占主导地位。此外，诱导对假定的二级表位的耐受性并不能预防临床复发。
