Kobeiter Hicham, Georgiades Christos S, Leakakos Tina, Torbenson Michael, Hong Kelvin, Geschwind Jean-Francois
University of Paris XII Henri Mondor Hospital, Paris, France.
Anticancer Res. 2007 Mar-Apr;27(2):755-60.
Our goal was to study the efficacy of liver cancer embolization with magnetically targeted Yttrium-90 labeled ferromagnetic particles and establish the biodistribution profile of these particles.
Of twenty rabbits, nine underwent transarterial radioembolization of implanted Vx-2 tumor with increasing 90Y-MTC doses, three were treated with carrier particles alone, four remained untreated and four were sacrificed early to document biodistribution. At various intervals, animals were sacrificed and biodistribution, liver cancer viability and toxicity were measured.
There was a dose related degree of tumor necrosis, with greater than 90 Gy yielding 100% necrosis (baseline 50%). Blood radioactivity one hour post-radioembolization was less than 0.0275 microCi/g. No hematological toxicity was observed. Except for the non-targeted right liver lobe, organ radioactivity levels were within tolerance levels. Significant left (targeted) hepatic lobe necrosis was seen in subjects receiving high doses.
Hepatic arterial radioembolization with 9Y-MTC bolstered by external magnetic field has significant tumoricidal effect and a favorable biodistribution profile.
我们的目标是研究用磁靶向钇 - 90标记的铁磁颗粒进行肝癌栓塞的疗效，并确定这些颗粒的生物分布情况。
20只兔子中，9只接受了递增剂量的90Y - MTC对植入的VX - 2肿瘤进行经动脉放射性栓塞，3只仅用载体颗粒治疗，4只未治疗，4只早期处死以记录生物分布。在不同时间间隔处死动物，测量生物分布、肝癌活力和毒性。
肿瘤坏死程度与剂量相关，大于90 Gy时产生100%坏死（基线为50%）。放射性栓塞后1小时血液放射性小于0.0275微居里/克。未观察到血液学毒性。除了非靶向的右肝叶，器官放射性水平在耐受范围内。接受高剂量的受试者可见明显的左（靶向）肝叶坏死。
在外部磁场支持下用9Y - MTC进行肝动脉放射性栓塞具有显著的杀瘤作用和良好的生物分布情况。
