Gormus Uzay, Ergen Arzu, Yilmaz Hulya, Dalan Burak, Berkman Sinan, Isbir Turgay
Istanbul University, Institute for Experimental Medical Research, Department of Molecular Medicine, Capa, Istanbul, Turkey.
Anticancer Res. 2007 Mar-Apr;27(2):991-4.
The Fas receptor is known to be widely expressed in various tissues and FasL is highly expressed on cells of the immune system and also on cells of immune-privileged areas such as the eyes and brain. Ovarian cells are known to exhibit marked FasL immunoreactivity throughout follicular development; there may also be a relationship between Fas and FasL polymorphisms and the immune privileges of the epithelial ovarian cells.
The study included 47 epithelial ovarian carcinoma patients and 41 healthy subjects. Polymerase chain reaction (PCR) and restriction endonucleases were used to determine the polymorphic Fas and FasL genes.
The FasL CC genotype was found to increase the risk of ovarian carcinoma and a protective effect of the GGCT genotype was observed.
Because of the expressional aspects of the FasL-844T --> C polymorphism, individuals carrying the FasL-844C allele would be expected to have higher FasL expression on tumour cells compared with those carrying the FasL-844T allele. People with such a genotype show a tendency to develop various tumours.
已知Fas受体在多种组织中广泛表达，FasL在免疫系统细胞以及免疫豁免区域（如眼睛和大脑）的细胞上高表达。已知卵巢细胞在整个卵泡发育过程中表现出明显的FasL免疫反应性；Fas和FasL多态性与上皮性卵巢细胞的免疫豁免之间可能也存在关联。
该研究纳入了47例上皮性卵巢癌患者和41名健康受试者。采用聚合酶链反应（PCR）和限制性内切酶来确定Fas和FasL基因的多态性。
发现FasL CC基因型会增加卵巢癌风险，并且观察到GGCT基因型具有保护作用。
由于FasL - 844T→C多态性的表达情况，与携带FasL - 844T等位基因的个体相比，携带FasL - 844C等位基因的个体的肿瘤细胞上预计会有更高的FasL表达。具有这种基因型的人有发生各种肿瘤的倾向。
