[促肾上腺皮质激素释放因子片段CRF4 - 6对大鼠血糖水平和体温的影响]

[Effect of corticoliberin fragment CRF4-6 on blood glucose level and body temperature of rats].

作者信息

Makarenko E Iu, Kondrashev-Lugovskiĭ A S, Andreeva L A, Mart'ianov A A

出版信息

Ross Fiziol Zh Im I M Sechenova. 2007 Jan;93(1):55-62.

Abstract

The effects of tripeptide corticoliberin fragment CRF4-6 (Pro-Pro-Ile) on blood glucose level and the rat body temperatire were investigated. Intracerebroventricularly injected CRF4-6 (6, 30, 150 nmol/head) causes a dosedependent hyperglycemia and hyperthermia in anaesthetized animals. Corticotropin releasing factor antagonist alpha-helical CRF4-6 (6.5 nmol/head) abolishes the influence of tripeptide CRF4-6 (6 nmol/head) on blood glucose level and body temperature of rats. Bilateral adrenalectomy has no effect on tripeptide-induced hyperglycemia and hyperthemia. This result indicates that hyperglycemic and hyperthermal effects of tripeptide occur independently of adrenal gland catecholamines. In addition, non-pituitary corticoliberin receptors are involved in CRF4-6 influences on blood glucose level and body temperature.

摘要

研究了三肽促肾上腺皮质激素释放因子片段CRF4-6（脯氨酸-脯氨酸-异亮氨酸）对血糖水平和大鼠体温的影响。脑室内注射CRF4-6（6、30、150 nmol/只）可使麻醉动物出现剂量依赖性高血糖和体温升高。促肾上腺皮质激素释放因子拮抗剂α-螺旋CRF4-6（6.5 nmol/只）可消除三肽CRF4-6（6 nmol/只）对大鼠血糖水平和体温的影响。双侧肾上腺切除术对三肽诱导的高血糖和体温升高无影响。该结果表明，三肽的高血糖和体温升高作用独立于肾上腺儿茶酚胺发生。此外，非垂体促肾上腺皮质激素释放因子受体参与了CRF4-6对血糖水平和体温的影响。