Makarenko E Iu, Tsvirkun D V, Andreeva L A, Martt'ianov A A
Zh Vyssh Nerv Deiat Im I P Pavlova. 2005 May-Jun;55(3):371-7.
The effects of tripeptide corticoliberin fragment CRF4-6 (icv; 6, 30, and 150 nmol/head) on behaviour of rats were investigated under non-stressing and stressing conditions. CRF4-6 activated rat behaviour under non-stressing conditions (home cage): the duration of locomotion and exploratory behaviour was increased whereas the duration of passive behaviour and sleep was decreased. On the other hand, CRF4-6 suppressed the rat exploratory behaviour under stressing conditions (elevated plus-maze): the duration of non-exploratory behaviour was increased; numbers of rearings and leanings out to open arms were reduced. All observed effects of the tripeptide CRF4-6 were dose-dependent. Behavioural effects of the tripeptide were similar to the well-known action of the whole corticoliberin molecule. Therefore we suggest that CRF4-6 is located in the active part of CRF or it can be a physiologically active corticoliberin derivative.
研究了三肽促肾上腺皮质激素释放因子片段CRF4 - 6（脑室内注射；6、30和150 nmol/只）在非应激和应激条件下对大鼠行为的影响。在非应激条件下（饲养笼），CRF4 - 6激活大鼠行为：运动和探索行为的持续时间增加，而被动行为和睡眠的持续时间减少。另一方面，在应激条件下（高架十字迷宫），CRF4 - 6抑制大鼠的探索行为：非探索行为的持续时间增加；竖毛和向开放臂探出身体的次数减少。三肽CRF4 - 6的所有观察到的效应均呈剂量依赖性。该三肽的行为效应与整个促肾上腺皮质激素释放因子分子的已知作用相似。因此，我们认为CRF4 - 6位于促肾上腺皮质激素释放因子的活性部分，或者它可能是一种具有生理活性的促肾上腺皮质激素释放因子衍生物。
