用99mTc标记的抗癌胚抗原单克隆抗体CL58对局部复发性直肠癌进行免疫闪烁显像。
Immunoscintigraphy of local recurrent rectal cancer with 99mTc-labeled anti-CEA monoclonal antibody CL58.
作者信息
Yao Yun-Feng, Yang Zhi, Li Zhen-Fu, Gu Jin
机构信息
Peking University School of Oncology, Beijing 100036, China.
出版信息
World J Gastroenterol. 2007 Mar 28;13(12):1841-6. doi: 10.3748/wjg.v13.i12.1841.
AIM
To explore a specific diagnostic method for local recurrent rectal cancer.
METHODS
Immunoscintigraphy with (99m)Tc-labeled anti-CEA monoclonal antibody (MoAb) CL-58 was performed for patients suspected of having a postoperative local recurrent rectal cancer and the findings were compared with the results of conventional imaging and pathology.
RESULTS
A total of 36 patients with a suspected local recurrent rectal cancer underwent immunoscintigraphy with (99m)Tc-conjugated CL58. Local recurrence of rectal cancer was identified in 31 patients and established in 30 during operation, endoscopy and pathological examination. No local recurrence was found in 5 patients without specific accumulation of (99m)Tc during the follow-up. Immunoscintigraphy had a positive rate of 86.11%, a specificity of 83.33%, and a sensitivity of 100%.
CONCLUSION
Immunoscintigraphy has a highly specific and predictive value for detecting local recurrent rectal cancer, especially after abdominal perineal resection (APR).
目的
探索局部复发性直肠癌的特异性诊断方法。
方法
对疑似术后局部复发性直肠癌的患者进行用（99m）锝标记的抗癌胚抗原单克隆抗体（MoAb）CL-58的免疫闪烁显像，并将结果与传统影像学和病理学结果进行比较。
结果
共有36例疑似局部复发性直肠癌的患者接受了用（99m）锝结合的CL58进行的免疫闪烁显像。31例患者被诊断为直肠癌局部复发，30例在手术、内镜检查和病理检查中得以确诊。5例在随访期间未发现（99m）锝特异性聚集的患者未出现局部复发。免疫闪烁显像的阳性率为86.11%，特异性为83.33%，敏感性为100%。
结论
免疫闪烁显像对检测局部复发性直肠癌具有高度特异性和预测价值，尤其是在腹会阴联合切除术（APR）后。
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