Fass Leonard
GE Healthcare, 352 Buckingham Avenue, Slough, SL1 4ER, UK.
Mol Oncol. 2008 Aug;2(2):115-52. doi: 10.1016/j.molonc.2008.04.001. Epub 2008 May 10.
Multiple biomedical imaging techniques are used in all phases of cancer management. Imaging forms an essential part of cancer clinical protocols and is able to furnish morphological, structural, metabolic and functional information. Integration with other diagnostic tools such as in vitro tissue and fluids analysis assists in clinical decision-making. Hybrid imaging techniques are able to supply complementary information for improved staging and therapy planning. Image guided and targeted minimally invasive therapy has the promise to improve outcome and reduce collateral effects. Early detection of cancer through screening based on imaging is probably the major contributor to a reduction in mortality for certain cancers. Targeted imaging of receptors, gene therapy expression and cancer stem cells are research activities that will translate into clinical use in the next decade. Technological developments will increase imaging speed to match that of physiological processes. Targeted imaging and therapeutic agents will be developed in tandem through close collaboration between academia and biotechnology, information technology and pharmaceutical industries.
多种生物医学成像技术应用于癌症治疗的各个阶段。成像在癌症临床方案中起着至关重要的作用，能够提供形态、结构、代谢和功能信息。与其他诊断工具（如体外组织和体液分析）相结合有助于临床决策。混合成像技术能够提供补充信息，以改进分期和治疗规划。图像引导和靶向微创治疗有望改善治疗效果并减少副作用。通过基于成像的筛查早期发现癌症可能是某些癌症死亡率降低的主要原因。受体、基因治疗表达和癌症干细胞的靶向成像研究活动将在未来十年转化为临床应用。技术发展将提高成像速度以匹配生理过程。通过学术界与生物技术、信息技术和制药行业的密切合作，将同步开发靶向成像和治疗药物。
