Magyari Lili, Faragó Bernadett, Bene Judit, Horvatovich Katalin, Lakner Lilla, Varga Márta, Figler Mária, Gasztonyi Beáta, Mózsik Gyula, Melegh Béla
Department of Medical Genetics and Child Development, University of Pecs, H-7624 Pecs, Szigeti 12, Hungary.
World J Gastroenterol. 2007 Apr 21;13(15):2205-8. doi: 10.3748/wjg.v13.i15.2205.
The goal of the current work was to analyse the prevalence of the +49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohnos disease (CD) and ulcerative colitis (UC).
A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism (SNP). The genotypes were determined by using PCR/RFLP test.
The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively.
The results of the current study show that carriage of the +49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.
当前研究的目的是分析细胞毒性T淋巴细胞抗原4基因（CTLA4）+49A/G变体在匈牙利克罗恩病（CD）和溃疡性结肠炎（UC）患者中的流行情况。
对总共130名无亲缘关系的CD患者、150名UC患者以及170名匹配的对照进行单核苷酸多态性（SNP）基因分型。通过PCR/RFLP检测确定基因型。
CD组中G等位基因频率和GG基因型的流行率分别为38.1%和12.3%，UC患者中分别为40.6%和18.6%，对照组中分别为37.4%和15.9%。
当前研究结果表明，在匈牙利人群中，杂合或纯合形式携带+49G SNP不会增加患CD或UC的风险。
