在匈牙利人群样本中，细胞毒性T淋巴细胞相关基因CTLA4 +49A/G多态性与克罗恩病和溃疡性结肠炎无关联。
No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples.
作者信息
Magyari Lili, Faragó Bernadett, Bene Judit, Horvatovich Katalin, Lakner Lilla, Varga Márta, Figler Mária, Gasztonyi Beáta, Mózsik Gyula, Melegh Béla
机构信息
Department of Medical Genetics and Child Development, University of Pecs, H-7624 Pecs, Szigeti 12, Hungary.
出版信息
World J Gastroenterol. 2007 Apr 21;13(15):2205-8. doi: 10.3748/wjg.v13.i15.2205.
AIM
The goal of the current work was to analyse the prevalence of the +49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohnos disease (CD) and ulcerative colitis (UC).
METHODS
A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism (SNP). The genotypes were determined by using PCR/RFLP test.
RESULTS
The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively.
CONCLUSION
The results of the current study show that carriage of the +49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.
目的
当前研究的目的是分析细胞毒性T淋巴细胞抗原4基因（CTLA4）+49A/G变体在匈牙利克罗恩病（CD）和溃疡性结肠炎（UC）患者中的流行情况。
方法
对总共130名无亲缘关系的CD患者、150名UC患者以及170名匹配的对照进行单核苷酸多态性（SNP）基因分型。通过PCR/RFLP检测确定基因型。
结果
CD组中G等位基因频率和GG基因型的流行率分别为38.1%和12.3%，UC患者中分别为40.6%和18.6%，对照组中分别为37.4%和15.9%。
结论
当前研究结果表明，在匈牙利人群中，杂合或纯合形式携带+49G SNP不会增加患CD或UC的风险。
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