Inflammation Research, Amgen, Seattle, WA 98119, USA.
Inflamm Res. 2010 Jan;59(1):1-14. doi: 10.1007/s00011-009-0091-x.
The intestine is subjected to a barrage of insults from food, bacterial flora, and pathogens. Despite this constant antigenic challenge, the mucosal tissues lining the intestinal tract remain largely under control. The mechanisms regulating the homeostatic balance in the gut have been investigated for many years by many groups, but the precise nature of the regulatory control remains elusive. In this review, we provide an overview of pathways proposed to be involved in dampening the inflammatory response and maintaining the homeostatic balance in the intestine, and how these pathways may be disrupted in ulcerative colitis and Crohn's disease.
肠道受到食物、细菌菌群和病原体的持续侵害。尽管面临持续的抗原性挑战，但肠道黏膜组织仍基本处于控制之下。多年来，许多研究小组一直在研究调节肠道内稳态平衡的机制，但确切的调控性质仍然难以捉摸。在这篇综述中，我们概述了被认为参与抑制炎症反应和维持肠道内稳态平衡的途径，以及这些途径在溃疡性结肠炎和克罗恩病中可能被破坏的方式。
