Crawford Julie T, Edelman Alison B, Pereira Leonardo, Bednarek Paula, Buckmaster John
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA.
Am J Obstet Gynecol. 2007 May;196(5):e38-9. doi: 10.1016/j.ajog.2006.10.389.
This study was undertaken to determine whether vasopressin decreases uterine artery blood flow and blood loss in early second-trimester surgical abortions (dilation and evacuation).
Randomized, double blind, placebo-controlled trial of a saline paracervical block with or without vasopressin before dilation and evacuation. Uterine artery pulsatility index and blood loss were measured.
Demographics were similar in both groups (mean gestational age 16.8 weeks, SD 1.7). Of 35 randomly assigned patients, Doppler waveforms were adequate in 28 patients (vasopressin, n = 13; placebo, n = 15). The mean difference in uterine artery pulsatility index before and after injection between groups was not significantly different (P = .14). Procedural blood loss was no different.
Paracervical vasopressin compared to placebo injection did not result in significant changes in uterine artery pulsatility index in early second-trimester dilation and evacuation procedures.
本研究旨在确定血管加压素是否会减少孕中期手术流产（扩张刮宫术）时的子宫动脉血流量和失血量。
在扩张刮宫术前，对宫颈旁阻滞注射生理盐水加或不加血管加压素进行随机、双盲、安慰剂对照试验。测量子宫动脉搏动指数和失血量。
两组的人口统计学特征相似（平均孕周16.8周，标准差1.7）。在35例随机分配的患者中，28例患者的多普勒波形数据充足（血管加压素组，n = 13；安慰剂组，n = 15）。两组注射前后子宫动脉搏动指数的平均差异无统计学意义（P = 0.14）。术中失血量也无差异。
在孕中期早期扩张刮宫术中，与注射安慰剂相比，宫颈旁注射血管加压素并未导致子宫动脉搏动指数发生显著变化。
