限水大鼠母鼠后代的肾发生增强。
Enhanced nephrogenesis in offspring of water-restricted rat dams.
作者信息
Mansano Roy, Desai Mina, Garg Ambica, Choi Gyu Yeon, Ross Michael G
机构信息
Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
出版信息
Am J Obstet Gynecol. 2007 May;196(5):480.e1-6. doi: 10.1016/j.ajog.2007.02.008.
OBJECTIVE
Maternal water restriction (WR) may induce offspring plasma hypertonicity and enhanced vasopressin secretory responses. We determined effects of pregnancy WR on offspring body composition, renal morphology, and blood pressure.
STUDY DESIGN
Pregnant Sprague Dawley rats (n = 21) were randomized to WR, pair-fed (PF), and control from embryo day (e) 10 to e21. Offspring body and organ weights and glomerular number and size were measured at birth and at 21 days of age. At 6 and 9 weeks, offspring blood pressure was determined.
RESULTS
At 21 days of age, WR offspring glomerular number was increased (17%; P < .05), whereas PF glomerular number was lower (4%), compared with controls. Systolic blood pressures were elevated in both WR and PF at both 6 and 9 weeks.
CONCLUSIONS
Pregnancy WR stimulates offspring nephrogenesis, suggesting an adaptive response to future dehydration. Programmed hypertension in WR and PF groups likely occurs via different mechanisms.
目的
母体限水（WR）可能会导致子代血浆高渗并增强血管加压素分泌反应。我们确定了孕期限水对子代身体组成、肾脏形态和血压的影响。
研究设计
将怀孕的斯普拉格-道利大鼠（n = 21）从胚胎第10天（e10）至第21天（e21）随机分为限水组、配对喂养组（PF）和对照组。在出生时和21日龄时测量子代的体重、器官重量以及肾小球数量和大小。在6周和9周时测定子代血压。
结果
在21日龄时，与对照组相比，限水组子代的肾小球数量增加（17%；P < 0.05），而配对喂养组的肾小球数量减少（4%）。在6周和9周时，限水组和配对喂养组的收缩压均升高。
结论
孕期限水会刺激子代肾发生，提示这是对未来脱水的一种适应性反应。限水组和配对喂养组的程序性高血压可能通过不同机制发生。
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