Griffin N, Allen D, Wort J, Rubens M, Padley S
Royal Brompton and Harefield NHS Trust, London, UK.
Clin Radiol. 2007 Jun;62(6):587-95. doi: 10.1016/j.crad.2007.01.013. Epub 2007 Apr 5.
To document the pulmonary vascular changes on thin-section computed tomography (CT) in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension, and to determine whether there is any correlation with pulmonary arterial pressures or the aetiology of pulmonary hypertension.
From the National Pulmonary Hypertension Database, we identified eight patients with idiopathic pulmonary arterial hypertension and 20 patients with Eisenmenger syndrome (secondary to a ventriculoseptal defect) who had also undergone contrast-enhanced thin-section CT. CT studies were reviewed for the presence of centrilobular nodules, mosaicism, neovascularity, and bronchial artery hypertrophy. Haemodynamic data were also reviewed.
Centrilobular nodules, mosaicism, and neovascularity were seen in both patient groups (p>0.05). A significantly higher number of enlarged bronchial arteries were seen in patients with Eisenmenger syndrome. There was no correlation with pulmonary arterial pressures.
Patients with idiopathic pulmonary arterial hypertension and Eisenmenger syndrome demonstrated similar pulmonary vascular changes on CT. These changes did not predict the underlying cause of pulmonary hypertension or its severity.
记录艾森曼格综合征和特发性肺动脉高压患者在薄层计算机断层扫描（CT）上的肺血管变化，并确定其与肺动脉压力或肺动脉高压病因之间是否存在相关性。
从国家肺动脉高压数据库中，我们确定了8例特发性肺动脉高压患者和20例艾森曼格综合征（继发于室间隔缺损）患者，他们也接受了对比增强薄层CT检查。对CT研究进行评估，以确定是否存在小叶中心结节、马赛克征、新生血管和支气管动脉增粗。还回顾了血流动力学数据。
两组患者均可见小叶中心结节、马赛克征和新生血管（p>0.05）。艾森曼格综合征患者中可见明显更多的支气管动脉增粗。与肺动脉压力无相关性。
特发性肺动脉高压和艾森曼格综合征患者在CT上表现出相似的肺血管变化。这些变化无法预测肺动脉高压的潜在病因或其严重程度。
