热休克蛋白27（HspB1）和αB-晶状体蛋白（HspB5）作为治疗靶点。

Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.

作者信息

Arrigo André-Patrick, Simon Stéphanie, Gibert Benjamin, Kretz-Remy Carole, Nivon Mathieu, Czekalla Anna, Guillet Dominique, Moulin Maryline, Diaz-Latoud Chantal, Vicart Patrick

机构信息

Laboratoire Stress, Chaperons et Mort Cellulaire, CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Lyon 1, Bat. Gregor Mendel, 16 Rue Dubois, F-69622, Villeurbanne Cedex, France.

出版信息

FEBS Lett. 2007 Jul 31;581(19):3665-74. doi: 10.1016/j.febslet.2007.04.033. Epub 2007 Apr 24.

DOI:10.1016/j.febslet.2007.04.033

PMID:17467701

Abstract

Hsp27 and alphaB-crystallin are molecular chaperones that are constitutively expressed in several mammalian cells, particularly in pathological conditions. These proteins share functions as diverse as protection against toxicity mediated by aberrantly folded proteins or oxidative-inflammation conditions. In addition, these proteins share anti-apoptotic properties and are tumorigenic when expressed in cancer cells. This review summarizes the current knowledge about Hsp27 and alphaB-crystallin and the implications, either positive or deleterious, of these proteins in pathologies such as neurodegenerative diseases, myopathies, asthma, cataracts and cancers. Approaches towards therapeutic strategies aimed at modulating the expression and/or the activities of Hsp27 and alphaB-crystallin are presented.

摘要

热休克蛋白27（Hsp27）和αB-晶状体蛋白是分子伴侣，在多种哺乳动物细胞中组成性表达，尤其是在病理条件下。这些蛋白质具有多种功能，包括保护细胞免受异常折叠蛋白介导的毒性或氧化炎症状态的影响。此外，这些蛋白质具有抗凋亡特性，在癌细胞中表达时具有致瘤性。本综述总结了目前关于Hsp27和αB-晶状体蛋白的知识，以及这些蛋白质在神经退行性疾病、肌病、哮喘、白内障和癌症等病理状态中的积极或有害影响。文中还介绍了旨在调节Hsp27和αB-晶状体蛋白表达和/或活性的治疗策略。