Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.
作者信息
Seeds Andrew M, Frederick Joshua P, Tsui Marco M K, York John D
机构信息
Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, P.O. Box 3813, Durham, NC 27710, USA.
出版信息
Adv Enzyme Regul. 2007;47:10-25. doi: 10.1016/j.advenzreg.2006.12.019. Epub 2007 Jan 5.
Abstract
摘要
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The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.Yng1p植物同源结构域指是一种甲基化组蛋白结合模块，可识别赖氨酸4甲基化的组蛋白H3。
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Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.核孔蛋白Gle1及其共激活因子InsP6对DExD/H盒蛋白Dbp5的激活是mRNA输出所必需的。
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Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export.肌醇六磷酸和Gle1激活DEAD盒蛋白Dbp5以促进核mRNA输出。
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Nature. 2006 Jul 6;442(7098):91-5. doi: 10.1038/nature04802. Epub 2006 May 21.
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Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.ING2植物同源结构域识别组蛋白H3K4me3的分子机制
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A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.NURF的一个PHD指结构域将组蛋白H3赖氨酸4三甲基化与染色质重塑联系起来。
Nature. 2006 Jul 6;442(7098):86-90. doi: 10.1038/nature04815. Epub 2006 May 21.
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ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.ING2的PHD结构域将组蛋白H3赖氨酸4甲基化与活性基因抑制联系起来。
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