Vitoux Dominique, Nasr Rihab, de The Hugues
CNRS UMR 7151, Université Paris 7, Equipe labellisée par la Ligue Nationale contre le Cancer, Hôpital Saint-Louis (APHP), 1 av Claude Vellefaux, 75475 Paris Cedex 10, France.
Int J Biochem Cell Biol. 2007;39(6):1063-70. doi: 10.1016/j.biocel.2007.01.028. Epub 2007 Mar 21.
Pathogenesis of acute promyelocytic leukemia appears to be one of the best understood among human malignancies. The ability of retinoic acid (RA) and arsenic trioxide to directly target the oncogenic promyelocytic leukemia-retinoic receptor A (PML-RARA) fusion protein also made this disease the first model for oncogene-targeted therapies. A set of recent data has significantly increased the complexity of our view of acute promyelocytic leukemia pathogenesis, as well as of therapeutic response. This review summarizes and discusses these findings, which yield novels questions and models.
急性早幼粒细胞白血病的发病机制似乎是人类恶性肿瘤中最容易理解的机制之一。维甲酸（RA）和三氧化二砷直接作用于致癌性早幼粒细胞白血病-维甲酸受体A（PML-RARA）融合蛋白的能力，也使这种疾病成为癌基因靶向治疗的首个模型。最近的一系列数据显著增加了我们对急性早幼粒细胞白血病发病机制以及治疗反应认识的复杂性。这篇综述总结并讨论了这些发现，它们提出了新的问题并建立了新的模型。
