Tanchoco Celeste C, Cruz Arsenia J, Rogaccion Jossie M, Casem Rosemarie S, Rodriguez Marietta P, Orense Consuelo L, Hermosura Lilibeth C
Clinical Nutrition Section- Nutrition Science and Technology Division, Food and Nutrition Research Institute, Department of Science and Technology, Gen. Santos Ave, Bicutan, Taguig, Philippines.
Asia Pac J Clin Nutr. 2007;16(2):286-92.
This study was undertaken to determine the effect of medium-chain triglyceride (MCT) oil supplementation on the duration and episodes of diarrhea attacks, and specifically its effect on the clinical manifestations of patients. Seventeen children aged 6 months to 47 months old with a mean age of 19.6 months, suffering from acute diarrhea at the Pediatric Ward of the Philippine General Hospital Medical Center and other neighboring health centers were studied. A double-blind randomized design was employed. Physical and clinical assessment was performed by a physician prior to enrolment in the study. Dietary, anthropometric, and biochemical assessment were undertaken by clinical investigators before and after the supplementation. The subjects were randomly assigned to either the MCT oil- supplemented diet or the non-MCT oil diet. Daily monitoring of food intake and the frequency or episodes of diarrhea attacks was done. Subjects were closely monitored for any possible adverse reactions. The baseline characteristics of the subjects were not significantly different for any of age, height, weight, cholesterol or triglyceride concentrations between the two groups. Nutrient intakes at baseline and during intervention were also not significantly different. There were no differences in cholesterol and triglyceride between the two groups after supplementation. Stool frequencies of the MCT group and the non-MCT group at baseline, after the 6th hr, and at 12th hour, were not different. No subject developed fat malabsorption during the intervention, as assessed with Sudan Black stain. There was statistical significant difference in the rate of weight gain among subjects in the MCT group compared to subjects in the non-MCT group , but a trend in this direction (0.22 + 0.22 kg/day vs -.048 + .26 kg/day), (p=.042). MCT oil may promote weight gain (although what this constitutes in body compositional terms is uncertain) and shows a trend towards shorter duration of intervention among children with acute diarrhea. Limited sample size precludes conclusions on these possibilities. MCT oil did not cause vomiting, dehydration, or fat intolerance. MCT oil did not cause an elevation in cholesterol and triglyceride levels. More studies, with larger sample size, and longer duration will be worthwhile to assess the effect of MCT oil on childhood diarrhea.
本研究旨在确定补充中链甘油三酯（MCT）油对腹泻发作的持续时间和发作次数的影响，特别是其对患者临床表现的影响。对菲律宾总医院医疗中心儿科病房及其他邻近健康中心的17名年龄在6个月至47个月之间、平均年龄为19.6个月的急性腹泻儿童进行了研究。采用双盲随机设计。在研究入组前由医生进行体格和临床评估。临床研究人员在补充前后进行饮食、人体测量和生化评估。受试者被随机分配到补充MCT油饮食组或非MCT油饮食组。每天监测食物摄入量和腹泻发作的频率或次数。密切监测受试者是否有任何可能的不良反应。两组在年龄、身高、体重、胆固醇或甘油三酯浓度方面，受试者的基线特征没有显著差异。基线时和干预期间的营养摄入量也没有显著差异。补充后两组的胆固醇和甘油三酯没有差异。MCT组和非MCT组在基线时、第6小时后和第12小时的粪便频率没有差异。用苏丹黑染色评估，干预期间没有受试者出现脂肪吸收不良。与非MCT组的受试者相比，MCT组受试者的体重增加率有统计学显著差异，但有此趋势（0.22±0.22kg/天对-0.048±0.26kg/天），（p = 0.042）。MCT油可能促进体重增加（尽管这在身体成分方面意味着什么尚不确定），并且在急性腹泻儿童中显示出干预持续时间较短的趋势。样本量有限妨碍了对这些可能性得出结论。MCT油不会引起呕吐、脱水或脂肪不耐受。MCT油不会导致胆固醇和甘油三酯水平升高。进行更多样本量更大、持续时间更长的研究，将有助于评估MCT油对儿童腹泻的影响。
