Murrell J C, Robertson S A, Taylor P M, McCown J L, Bloomfield M, Sear J W
Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands.
Vet Rec. 2007 Apr 28;160(17):578-83. doi: 10.1136/vr.160.17.578.
Six domestic shorthair cats, aged three to four years and weighing 5.1 to 7.4 kg, were used to assess the thermal antinociceptive effect of a transdermal buprenorphine patch, designed to supply 35 mug buprenorphine/hour, which was applied to the shaved thorax. The cats' thermal thresholds were tested before the patch was applied and two, four, six, eight, 10, 12, 14 and 16 hours after it had been applied, and then every six hours until it was removed after 72 hours, and for a further 24 hours afterwards. Blood was collected at each time to measure the plasma concentration of buprenorphine. The patches did not produce a significant change in the thermal thresholds of the cats throughout the testing period. The mean (sd) peak plasma buprenorphine concentration was 10 (0.81) ng/ml.
选用6只3至4岁、体重5.1至7.4千克的家养短毛猫，以评估一种旨在每小时提供35微克丁丙诺啡的透皮丁丙诺啡贴片的热抗伤害感受作用，该贴片贴于剃毛后的胸部。在贴片应用前以及应用后2、4、6、8、10、12、14和16小时测试猫的热阈值，然后每6小时测试一次，直至72小时后移除贴片，并在移除后再持续测试24小时。每次均采集血液以测量丁丙诺啡的血浆浓度。在整个测试期间，贴片未使猫的热阈值产生显著变化。丁丙诺啡血浆浓度的平均（标准差）峰值为10（0.81）纳克/毫升。
