Salles N
Geriatric Department, Hospital Xavier Arnozan, Pessac, France.
Dig Dis. 2007;25(2):112-7. doi: 10.1159/000099474.
The goal of this short review is to summarize recent data on gastrointestinal changes with aging, focusing on gastrointestinal motility disorders, and mucosal variations. First of all, this review focused on gastrointestinal motility disorders with aging, even though an increased prevalence of several gastrointestinal motor disorders (i.e., dysphagia, dyspepsia, anorexia, and constipation) occurs in older people, aging per se appears to have a minor direct effect on most gastrointestinal functions. Secondly, this review focused on histological changes with aging, i.e., regulation of gastrointestinal mucosal growth, gastrointestinal carcinogenesis, and gastric mucosal changes, especially changes in gastric acid secretion, bacterial overgrowth and its consequences on elderly patients.
这篇简短综述的目的是总结近期关于衰老过程中胃肠道变化的数据，重点关注胃肠动力障碍和黏膜变化。首先，尽管老年人中几种胃肠动力障碍（即吞咽困难、消化不良、厌食和便秘）的患病率有所增加，但衰老本身似乎对大多数胃肠功能只有较小的直接影响，本综述仍聚焦于衰老相关的胃肠动力障碍。其次，本综述聚焦于衰老过程中的组织学变化，即胃肠黏膜生长的调节、胃肠癌发生以及胃黏膜变化，特别是胃酸分泌的变化、细菌过度生长及其对老年患者的影响。
