Grassi M, Petraccia L, Mennuni G, Fontana M, Scarno A, Sabetta S, Fraioli A
Deparment Internal Medicine and Medical Disciplines, Unit of Internal Medicine E, Medical Therapy and Thermal Medicine, School of Specialization in Thermal Medicine, Rome, Italy.
Nutr Hosp. 2011 Jul-Aug;26(4):659-68. doi: 10.1590/S0212-16112011000400001.
This article describes changes in the basic digestive functions (motility, secretion, intraluminal digestion, absorption) that occur during aging. Elderly individuals frequently have oropharyngeal muscle dysmotility and altered swallowing of food. Reductions in esophageal peristalsis and lower esophageal sphincter (LES) pressures are also more common in the aged and may cause gastroesophageal reflux. Gastric motility and emptying and small bowel motility are generally normal in elderly subjects, although delayed motility and gastric emptying have been reported in some cases. The propulsive motility of the colon is also decreased, and this alteration is associated with neurological and endocrine-paracrine changes in the colonic wall. Decreased gastric secretions (acid, pepsin) and impairment of the mucous-bicarbonate barrier are frequently described in the elderly and may lead to gastric ulcer. Exocrine pancreatic secretion is often decreased, as is the bile salt content of bile. These changes represent the underlying mechanisms of symptomatic gastrointestinal dysfunctions in the elderly, such as dysphagia, gastroesophageal reflux disease, primary dyspepsia, irritable bowel syndrome, primary constipation, maldigestion, and reduced absorption of nutrients. Therapeutic management of these conditions is also described. The authors also review the gastrointestinal diseases that are more common in the elderly, such as atrophic gastritis, gastric ulcer, colon diverticulosis, malignant tumors, gallstones, chronic hepatitis, liver cirrhosis, Hepato Cellular Carcinoma (HCC), and chronic pancreatitis.
本文描述了衰老过程中发生的基本消化功能(运动、分泌、腔内消化、吸收)变化。老年人常出现口咽肌肉运动障碍和食物吞咽改变。食管蠕动和食管下括约肌(LES)压力降低在老年人中也更常见,可能导致胃食管反流。尽管在某些情况下有报道称老年受试者的胃动力和排空以及小肠动力延迟,但总体上一般是正常的。结肠的推进性动力也降低,这种改变与结肠壁的神经和内分泌旁分泌变化有关。老年人常出现胃酸分泌(酸、胃蛋白酶)减少和黏液 - 碳酸氢盐屏障受损,可能导致胃溃疡。外分泌性胰腺分泌通常减少,胆汁中的胆汁盐含量也减少。这些变化是老年人出现症状性胃肠功能障碍的潜在机制,如吞咽困难、胃食管反流病、原发性消化不良、肠易激综合征、原发性便秘、消化不良和营养吸收减少。本文还描述了这些病症的治疗管理。作者还回顾了老年人中更常见的胃肠道疾病,如萎缩性胃炎、胃溃疡、结肠憩室病、恶性肿瘤、胆结石、慢性肝炎、肝硬化、肝细胞癌(HCC)和慢性胰腺炎。
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