Minault S, Renard P, Faroux M J, Diebold M D, Carteret E, Zeitoun P
Service d'Hépato-Gastroentérologie, Hôpital Robert Debré, Reims.
Ann Gastroenterol Hepatol (Paris). 1991 Oct;27(5):193-7.
The aim of this study has been for one part to assess the obtaining of cytological and histological material from the same patients with the minimum amount of injections using a fine needle (diameter less than 1 mm) and also to evaluate the histological and cytological supply, individually and jointly in the diagnosis of abdominal tumors. Seventy lesions of which 58 hepatic have been punctured with fine needles of 20 (0.9 mm) to 22 G (0.7 mm). Material has been obtained in 98.6 per cent of cases for cytology and 54 per cent of cases for histology. Their respective sensitivity in the diagnosis of malignant tumors was 96.8 per cent and 86.8 per cent and was not improved by adjoint analysis. The specificity was 1 for cytology. The differential diagnosis in malignant hepatic tumors between hepatocarcinoma and metastasis was existent in 94.3 per cent of cases for cytology and 90 per cent for histology with no benefit coming from the association of two. In the group having hepatic metastasis without known primary cancer having found histological confirmation of the primary lesion, the cellular type has been revealed in exactitude in 94.4 per cent of cases with cytology and in 63.6 per cent with histology. No complications have been observed. The fine needle cytological aspiration ponction gives very satisfying results, comparable with regard to the diagnosis contribution to results of published studies, obtained with the use of coarse needle biopies. We suggest that fine needle ponction should be used preferentially and that coarse needle biopsy should be restricted to the few cases in which the former does not yield sufficient information.
本研究的目的一方面是评估使用细针(直径小于1毫米)以最少的注射次数从同一患者获取细胞学和组织学材料,同时评估组织学和细胞学样本在腹部肿瘤诊断中的单独及联合应用。70个病灶,其中58个肝脏病灶用20G(0.9毫米)至22G(0.7毫米)的细针进行了穿刺。细胞学材料获取率为98.6%,组织学材料获取率为54%。它们在恶性肿瘤诊断中的各自敏感性分别为96.8%和86.8%,联合分析并未提高敏感性。细胞学的特异性为1。肝细胞癌与转移瘤在恶性肝脏肿瘤中的鉴别诊断,细胞学诊断符合率为94.3%,组织学诊断符合率为90%,两者联合并无益处。在未发现原发性癌症但有肝脏转移且已获得原发性病变组织学证实的组中,细胞学准确揭示细胞类型的比例为94.4%,组织学为63.6%。未观察到并发症。细针细胞学穿刺抽吸取得了非常令人满意的结果,就诊断贡献而言,与已发表研究中使用粗针活检获得的结果相当。我们建议应优先使用细针穿刺,粗针活检应仅限于前者无法提供足够信息的少数情况。