Guadagni F, Roselli M, Ferroni P, Amato T, Colcher D, Greiner J W, Schlom J
Regina Elena National Cancer Institute, Rome, Italy.
Anticancer Res. 1991 Jul-Aug;11(4):1389-94.
Tumor-associated glycoprotein-72 (TAG-72) is a high molecular weight glycoprotein found in the sera of patients diagnosed with gastrointestinal and other malignancies. TAG-72 was detected in the serum of a significant percentage of patients whose CEA levels were negative which underscores the possibility of exploiting the complementarity of the two tumor markers in the diagnosis of gastrointestinal (G.I.) carcinoma. Moreover, the measurement of TAG-72 may also be clinically useful in discriminating malignant from benign effusions. Serum TAG-72 and CEA levels were evaluated longitudinally in a series of patients following resection of primary G.I. carcinomas. A consistent relationship between efficacy of the surgery and serum TAG-72 clearance was observed, and TAG-72 alone or in combination with CEA accurately predicted recurrence of malignant disease in greater than 90% of the patients. The results indicate that TAG-72 is a new human serum tumor marker which, measured alone or in combination with other well established markers, may improve the diagnosis and/or clinical management of malignant disease.
肿瘤相关糖蛋白72（TAG - 72）是一种高分子量糖蛋白，在被诊断患有胃肠道及其他恶性肿瘤患者的血清中被发现。在癌胚抗原（CEA）水平呈阴性的相当一部分患者血清中检测到了TAG - 72，这突出了利用这两种肿瘤标志物的互补性来诊断胃肠道（G.I.）癌的可能性。此外，检测TAG - 72在鉴别恶性与良性积液方面可能也具有临床实用性。在一系列原发性G.I.癌切除术后的患者中对血清TAG - 72和CEA水平进行了纵向评估。观察到手术疗效与血清TAG - 72清除之间存在一致关系，并且单独使用TAG - 72或与CEA联合使用能在超过90% 的患者中准确预测恶性疾病的复发。结果表明，TAG - 72是一种新的人类血清肿瘤标志物，单独检测或与其他成熟标志物联合检测，可能会改善恶性疾病的诊断和/或临床管理。
