与单纯性夜间遗尿症儿童相比，尿失禁儿童的糖胺聚糖排泄增加。
Increased excretion of glycosaminoglycans in children with urinary incontinence compared to those with monosymptomatic nocturnal enuresis.
作者信息
Ferrara Pietro, Marrone Giuseppina, Mastrangelo Antonio, Nicoletti Alessandro, Emmanuele Valentina, Fasano Alfonso
机构信息
Department of Pediatrics, Università Cattolica S. Cuore, A. Gemelli Hospital, Rome, Italy.
出版信息
Scand J Urol Nephrol. 2007;41(3):218-22. doi: 10.1080/00365590601068942.
OBJECTIVE
To analyse the urinary excretion of glycosaminoglycans (GAGs) in patients with either urinary incontinence or nocturnal enuresis.
MATERIAL AND METHODS
The study population comprised 65 patients with either nocturnal enuresis (n=34) or urinary incontinence (n=31) and 67 controls. Excretion of urinary GAGs was assessed using the sodium tetraborate-carbazole method.
RESULTS
GAG excretion in patients with urinary incontinence was significantly higher than that in controls (p<0.000129) and in children with nocturnal enuresis (p<0.016). There were no age or sex differences in GAG excretion in the three groups studied.
CONCLUSION
Increased GAG excretion in patients with urinary incontinence suggests an association with urothelial/detrusor pathology.
目的
分析尿失禁或夜间遗尿患者的糖胺聚糖（GAGs）尿排泄情况。
材料与方法
研究人群包括65例夜间遗尿患者（n = 34）或尿失禁患者（n = 31）以及67名对照者。采用四硼酸钠 - 咔唑法评估尿GAGs排泄情况。
结果
尿失禁患者的GAG排泄显著高于对照组（p < 0.000129）和夜间遗尿儿童（p < 0.016）。在研究的三组中，GAG排泄在年龄或性别上无差异。
结论
尿失禁患者GAG排泄增加提示与尿路上皮/逼尿肌病变有关。
Zotero 插件