Ferrara Pietro, Marrone Giuseppina, Mastrangelo Antonio, Nicoletti Alessandro, Emmanuele Valentina, Fasano Alfonso
Department of Pediatrics, Università Cattolica S. Cuore, A. Gemelli Hospital, Rome, Italy.
Scand J Urol Nephrol. 2007;41(3):218-22. doi: 10.1080/00365590601068942.
To analyse the urinary excretion of glycosaminoglycans (GAGs) in patients with either urinary incontinence or nocturnal enuresis.
The study population comprised 65 patients with either nocturnal enuresis (n=34) or urinary incontinence (n=31) and 67 controls. Excretion of urinary GAGs was assessed using the sodium tetraborate-carbazole method.
GAG excretion in patients with urinary incontinence was significantly higher than that in controls (p<0.000129) and in children with nocturnal enuresis (p<0.016). There were no age or sex differences in GAG excretion in the three groups studied.
Increased GAG excretion in patients with urinary incontinence suggests an association with urothelial/detrusor pathology.
分析尿失禁或夜间遗尿患者的糖胺聚糖（GAGs）尿排泄情况。
研究人群包括65例夜间遗尿患者（n = 34）或尿失禁患者（n = 31）以及67名对照者。采用四硼酸钠 - 咔唑法评估尿GAGs排泄情况。
尿失禁患者的GAG排泄显著高于对照组（p < 0.000129）和夜间遗尿儿童（p < 0.016）。在研究的三组中，GAG排泄在年龄或性别上无差异。
尿失禁患者GAG排泄增加提示与尿路上皮/逼尿肌病变有关。
