García Elizabeth, Jay David
Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología, Ignacio Chávez, México, D.F.
Arch Cardiol Mex. 2006 Oct-Dec;76 Suppl 4:S67-75.
Activation of cellular receptors by diverse stimuli induces dramatic changes in shape and function to respond to the new circumstances of the cell. This modified behavior depends on the reorganization of the peripheral actin meshwork. An outstanding example of these processes can be found in platelets, from which much of the information available on cytoskeletal function has been obtained. Among the many actin-crosslinking proteins like spectrin, fimbrin or alpha actinin, filamin a (FLNa) emerges as the one with the highest potential in initiating the polimerization of actin filaments (F-actin) during the formation of tridimensional actin gels. FLNa also links actin filaments to the cytosolic domain of many membrane glycoproteins in platelets through its C-terminal region. In addition to participating in cell shape changes, FLNa is a scaffoldding protein that recruits numerous proteins involved in a completely different set of functions, including signal transduction, gene transcription regulation, and receptor translocation; however, the physiological role of FLNa in these processes has remained elusive. The purpose of the present communication is to briefly describe the characteristics of the macromolecules able to interact with FLNa and to discuss a possible role of FLNa during the transduction of signals from those molecular elements in platelets.
多种刺激激活细胞受体可诱导细胞形态和功能发生显著变化，以应对细胞的新环境。这种改变后的行为依赖于外周肌动蛋白网络的重组。血小板就是这些过程的一个典型例子，目前关于细胞骨架功能的许多信息都来自血小板。在众多肌动蛋白交联蛋白中，如血影蛋白、丝束蛋白或α辅肌动蛋白，细丝蛋白A（FLNa）在三维肌动蛋白凝胶形成过程中启动肌动蛋白丝（F-肌动蛋白）聚合的潜力最大。FLNa还通过其C末端区域将肌动蛋白丝与血小板中许多膜糖蛋白的胞质结构域相连。除了参与细胞形态变化外，FLNa还是一种支架蛋白，可招募许多参与完全不同功能的蛋白质，包括信号转导、基因转录调控和受体转运；然而，FLNa在这些过程中的生理作用仍不清楚。本通讯的目的是简要描述能够与FLNa相互作用的大分子的特征，并讨论FLNa在血小板中这些分子元件的信号转导过程中可能发挥的作用。
