Kahn Jeffrey P
Center for Bioethics, University of Minnesota, Minneapolis, MN 55455, USA.
Cleve Clin J Med. 2007 Mar;74 Suppl 2:S49-50; discussion S51-9. doi: 10.3949/ccjm.74.suppl_2.s49.
Biomedical research is experiencing a crisis in public trust. Although the vast majority of clinical studies are conducted in an ethical fashion, public perceptions are fueled by well-publicized examples of unethical practices. Mistrust is further encouraged by the duality of the role of the clinical researcher, who is charged with both caring for patients and answering a research question. Disclosure is not adequate to fully address conflicts of interest in biomedical research; instead, efforts to protect patients' interests and enhance trust should combine disclosure with an attempt to reduce conflicts in the first place as much as possible.
生物医学研究正面临公众信任危机。尽管绝大多数临床研究都是以符合伦理的方式进行的，但不道德行为的公开实例加剧了公众的看法。临床研究人员角色的双重性进一步助长了不信任，临床研究人员既要负责照顾患者，又要回答研究问题。披露不足以充分解决生物医学研究中的利益冲突；相反，保护患者利益和增强信任的努力应将披露与尽可能从源头上减少冲突的尝试结合起来。
