Naik Suresh R, Desai Sandhya K, Nanda Rabindra K, Narayanan Mangalam S
Department of Pharmacology and Biotechnology, Principal K. M. Kundnani College of Pharmacy, Mumbai, India.
Arzneimittelforschung. 2007;57(3):171-9. doi: 10.1055/s-0031-1296601.
A new strain, Streptomyces sp. S24 was isolated from a soil sample collected from Japan. Preliminary morphological, cultural, physiological and biochemical studies on this strain were carried out. Under submerged culture conditions the strain produced heptaene polyene macrolide (SJA-95), which elicits promising antifungal activity in vitro against yeasts, filamentous fungi including clinical isolates and plant pathogens. Its antifungal activity is comparable to that of hamycin and amphotericin B. SJA-95 was found to be toxic when given by the parenteral route in mice and not absorbed by the oral route like other polyene heptaene macrolides. The physicochemical data, spectral studies and elemental analysis suggest that SJA-95 is a polyene macrolide antibiotic. However, the chemical structure needs to be elucidated by further spectroscopic studies viz. 13C NMR, FEB-MS, EL MS and other tests.
从日本采集的土壤样本中分离出一种新菌株，链霉菌属S24。对该菌株进行了初步的形态学、培养学、生理学和生物化学研究。在深层培养条件下，该菌株产生了七烯多烯大环内酯（SJA - 95），其在体外对酵母、丝状真菌（包括临床分离株和植物病原体）具有良好的抗真菌活性。其抗真菌活性与哈霉素和两性霉素B相当。发现SJA - 95通过非肠道途径给药时对小鼠有毒，且不像其他多烯七烯大环内酯那样通过口服途径吸收。物理化学数据、光谱研究和元素分析表明SJA - 95是一种多烯大环内酯抗生素。然而，其化学结构需要通过进一步的光谱研究来阐明，即13C NMR、FEB - MS、EL MS和其他测试。
