Lugović Liborija, Situm Mirna, Buljan Marija, Poduje Sanja, Sebetić Klaudija
Department of Dermatology and Venereology, University Hospital "Sestre milosrdnice", Zagreb, Croatia.
Coll Antropol. 2007 Jan;31 Suppl 1:7-11.
Although there is no routine procedure for determination of serum markers in patients with malignant melanoma (MM), some markers are being studied as potentially useful prognostic tools. Serum lactate dehydrogenase (LDH), protein S-100B, melanoma-inhibiting activity (MIA) and tyrosinase may correlate with melanoma progression. In this study, the results of determination of S100 protein, LDH, MIA and tyrosinase in the serum of 50 patients with MM (stages I-IV) were determined. The increased values of MIA were found in 26% patients in stage I, while in 50% patients in stage IV Increased S-100 protein was found in 13% patients in stage I while in 50% patients in stage IV. The increased values of LDH were found in 26% patients in stage I, while in 25% patients in stage IV. The positive serum tyrosinase was noticed in 17.3% patients in stage II, while in 25% patients in stage IV. The obtained results have revealed no significant differences between the groups in higher and lower stages of the disease, indicating that blood markers are not reliable prognostic factors for MM progression.
尽管目前尚无用于检测恶性黑色素瘤（MM）患者血清标志物的常规程序，但一些标志物正作为潜在有用的预后工具进行研究。血清乳酸脱氢酶（LDH）、蛋白质S - 100B、黑色素瘤抑制活性（MIA）和酪氨酸酶可能与黑色素瘤进展相关。在本研究中，测定了50例MM患者（I - IV期）血清中S100蛋白、LDH、MIA和酪氨酸酶的检测结果。I期患者中26%的MIA值升高，而IV期患者中50%的MIA值升高。I期患者中13%的S - 100蛋白升高，而IV期患者中50%的S - 100蛋白升高。I期患者中26%的LDH值升高，而IV期患者中25%的LDH值升高。II期患者中17.3%的血清酪氨酸酶呈阳性，而IV期患者中25%的血清酪氨酸酶呈阳性。所得结果显示，疾病高低分期组之间无显著差异，表明血液标志物并非MM进展的可靠预后因素。
