Divanovic Senad, Trompette Aurelien, Petiniot Lisa K, Allen Jessica L, Flick Leah M, Belkaid Yasmine, Madan Rajat, Haky Jennifer J, Karp Christopher L
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
J Leukoc Biol. 2007 Aug;82(2):265-71. doi: 10.1189/jlb.0107021. Epub 2007 Apr 30.
As all immune responses have potential for damaging the host, tight regulation of such responses--in amplitude, space, time and character--is essential for maintaining health and homeostasis. It was thus inevitable that the initial wave of papers on the role of Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs) in activating innate and adaptive immune responses would be followed by a second wave of reports focusing on the mechanisms responsible for restraining and modulating signaling by these receptors. This overview outlines current knowledge and controversies about the immunobiology of the RP105/MD-1 complex, a modulator of the most robustly signaling TLR, TLR4.
由于所有免疫反应都有可能损害宿主，因此对这些反应在幅度、空间、时间和特性方面进行严格调控对于维持健康和体内平衡至关重要。因此，关于Toll样受体（TLR）、NOD样受体（NLR）和RIG-I样受体（RLR）在激活先天性和适应性免疫反应中作用的首批论文浪潮之后，不可避免地会迎来第二批报告，这些报告聚焦于负责抑制和调节这些受体信号传导的机制。本综述概述了关于RP105/MD-1复合物免疫生物学的当前知识和争议，该复合物是最强信号传导TLR即TLR4的调节剂。
