Broor Shobha, Bharaj Preeti
Department of Microbiology, All India Institute of Medical Sciences Hospital, New Delhi, India.
Ann N Y Acad Sci. 2007 Apr;1102:66-85. doi: 10.1196/annals.1408.005.
Pneumovirus infection remains a significant problem for both human and veterinary medicine. Both avian pneumovirus (aMPV, Turkey rhinotracheitis virus) and human metapneumovirus (hMPV) are pathogens of birds and humans, which are associated with respiratory tract infections. Based on their different genomic organization and low level of nucleotide (nt) and amino acid (aa) identity with paramyxoviruses in the genus Pneumovirus, aMPV and hMPV have been classified into a new genus referred to as Metapneumovirus. The advancement of our understanding of pneumovirus biology and pathogenesis of pneumovirus disease in specific natural hosts can provide us with strategies for vaccine formulations and combined antiviral and immunomodulatory therapies.
肺病毒感染对人类医学和兽医学来说仍然是一个重大问题。禽肺病毒（aMPV，火鸡鼻气管炎病毒）和人偏肺病毒（hMPV）分别是禽类和人类的病原体，都与呼吸道感染有关。基于它们不同的基因组结构以及与肺病毒属副粘病毒的核苷酸（nt）和氨基酸（aa）同源性较低，aMPV和hMPV已被归为一个新属，称为偏肺病毒属。深入了解肺病毒生物学特性以及特定自然宿主中肺病毒疾病的发病机制，可为我们提供疫苗研发策略以及抗病毒和免疫调节联合治疗方案。
