Honda Hirokazu, Hosaka Nozomu, Akizawa Tadao
Showa University School of Medicine, Department of Nephrology, Japan.
Clin Calcium. 2007 May;17(5):654-8.
Kidney is a central effector organ on calcium (Ca) and phosphate (P) homeostasis. Their homeostasis are mainly preserved by renal reabsorption and excretion, which often regulated through common hormonal signals, parathyroid hormone (PTH), vitamin D, and calcitonin. The hormones also involves phosphatonins as a circulating factor with potent phosphaturic activity and the key phosphatonin appears to be a fibroblast growth factor (FGF) 23. FGF23 is associated with vitamin D metabolism as well as tubular phosphate excretion. Moreover, recent study using animal models revealed the task of klotho protein, which gene functions as an aging-suppressor gene, for the regulation of FGF23 signaling, Ca(2+) absorption and vitamin D modulation in the kidney.
肾脏是钙（Ca）和磷（P）稳态的核心效应器官。它们的稳态主要通过肾脏的重吸收和排泄来维持，而这通常由常见的激素信号调节，如甲状旁腺激素（PTH）、维生素D和降钙素。这些激素还涉及磷调节素，它是一种具有强大促尿磷排泄活性的循环因子，关键的磷调节素似乎是成纤维细胞生长因子（FGF）23。FGF23与维生素D代谢以及肾小管磷排泄有关。此外，最近使用动物模型的研究揭示了klotho蛋白在调节肾脏中FGF23信号传导、Ca(2+)吸收和维生素D调节方面的作用，其基因起到衰老抑制基因的功能。
