Lackey Phillip L, Sargent Larry A, Wong Lesley, Brzezienski Mark, Kennedy J Woodfin
Department of Plastic Surgery, University of Tennessee College of Medicine-Chattanooga, Chattanooga, TN 37403, USA.
Ann Plast Surg. 2007 Mar;58(3):250-4. doi: 10.1097/01.sap.0000250842.96272.37.
Basal cell carcinoma is exceedingly common, but tumors >5 cm in size or giant basal cell carcinomas (GBCCs) are rare. We retrospectively review 10 GBCCs in 8 patients treated by aggressive surgical excision and reconstruction in a single operative procedure. With the exception of 1 chest lesion, all GBCCs involved the face or scalp. The 10 large defects were reconstructed with 5 free-tissue transfers, 2 pedicled musculocutaneous flaps, and 3 rotational skin flaps. There has been no evidence of local recurrence or metastasis in a mean follow-up of 29 months. Neglect has a well-established role in the presence of GBCCs, with undiagnosed preexisting medical problems also common. Surgical excision and reconstruction is the treatment of choice and can be readily accomplished in a single procedure with few complications, good oncologic control, and acceptable cosmetic results.
基底细胞癌极为常见，但肿瘤大小超过5厘米的巨大基底细胞癌（GBCC）却很罕见。我们回顾性分析了8例患者的10例GBCC，这些患者均在一次手术中接受了积极的手术切除和重建治疗。除1例胸部病变外，所有GBCC均累及面部或头皮。10处大的缺损通过5次游离组织移植、2次带蒂肌皮瓣和3次旋转皮瓣进行了重建。平均随访29个月，未发现局部复发或转移的证据。忽视在GBCC的发生中起着既定作用，未被诊断出的既往存在的医疗问题也很常见。手术切除和重建是首选治疗方法，可在一次手术中轻松完成，并发症少，肿瘤控制良好，美容效果可接受。
