Kalinchenko S Iu, Vorslov L O, Aglamazian N L, Morgunov L Iu
Urologiia. 2007 Jan-Feb(1):57, 59-61.
Partial androgen deficiency of aging male (PADAM) manifests with sexual dysfunction and is associated with many diseases, primarily, cardiovascular. After the age of 30-40 a testosterone level falls 1-2% a year. The number of men with testosterone deficiency grows from 8% in 40-60-year-olds to 85% at the age over 80 years. Low testosterone correlates with such risk factors of cardiovascular diseases as dyslipidemia, atherosclerosis, low fibrinolysis, insulin resistance and abdominal obesity. Correction of androgenic deficiency can be conducted with the drug androgel which represents a new system of transdermal testosterone delivery. In contrast to vasoactive drugs, androgel affects pathogenetic mechanisms of erectile dysfunction and thus attenuates factors of cardiovascular risk. Androgel is used externally and is more effective than intramuscular and oral analogues. Also, the drug improves lipid spectrum. By activating lipolysis, testosterone reduces the amount of visceral fat thus lowering insulin resistance. A vasodilating effect of androgel positively influences cardiovascular system and penile vessels. The drug acts fast, is effective and safe. Therefore, it can be recommended for correction of erectile dysfunction in patients with old age androgen deficiency and concurrent cardiovascular diseases.
老年男性部分雄激素缺乏症（PADAM）表现为性功能障碍，且与许多疾病相关，主要是心血管疾病。30 - 40岁以后，睾酮水平每年下降1 - 2%。睾酮缺乏男性的数量从40 - 60岁年龄段的8%增长至80岁以上年龄段的85%。低睾酮与心血管疾病的危险因素相关，如血脂异常、动脉粥样硬化、低纤维蛋白溶解、胰岛素抵抗和腹部肥胖。雄激素缺乏的纠正可使用药物Androgel，它是一种新的经皮睾酮给药系统。与血管活性药物不同，Androgel影响勃起功能障碍的发病机制，从而减轻心血管风险因素。Androgel为外用药物，比肌肉注射和口服类似物更有效。此外，该药物可改善血脂谱。通过激活脂肪分解，睾酮减少内脏脂肪量，从而降低胰岛素抵抗。Androgel的血管舒张作用对心血管系统和阴茎血管有积极影响。该药物起效快，有效且安全。因此，对于老年雄激素缺乏并发心血管疾病患者的勃起功能障碍纠正，它是可以推荐使用的。
