Falk S, Schütze U, Guth H, Stutte H J
Department of Pathology, J. W. Goethe University Frankfurt.
Eur J Pediatr Surg. 1991 Oct;1(5):277-81. doi: 10.1055/s-2008-1042505.
As part of a retrospective study 47 appendices from patients with a clinical and morphologic diagnosis of chronic recurrent appendicitis were studied by morphologic and immunohistochemical methods. Appendices with chronic recurrent appendicitis histologically show chronic active inflammation with increased numbers of immunocompetent cells, mostly T lymphocytes and subsequent scarring. In addition, there is an increase in the number of neural cells. Apparently the secretion of neurotropic inflammatory mediators, especially by activated and degranulating eosinophils, leads to a stimulation of nociceptive receptors and thus to the clinical symptoms. The diagnosis of recurrent chronic appendicitis is thus warranted in these cases not only clinically but also on the basis of histologic and immunohistochemical findings.
作为一项回顾性研究的一部分，我们采用形态学和免疫组织化学方法对47例临床和形态学诊断为慢性复发性阑尾炎患者的阑尾进行了研究。组织学上，慢性复发性阑尾炎的阑尾表现为慢性活动性炎症，免疫活性细胞数量增加，主要是T淋巴细胞，随后出现瘢痕形成。此外，神经细胞数量也增加。显然，尤其是活化和脱颗粒的嗜酸性粒细胞分泌的神经营养性炎症介质会刺激伤害性感受器，从而导致临床症状。因此，在这些病例中，不仅在临床上，而且基于组织学和免疫组织化学结果，复发性慢性阑尾炎的诊断都是合理的。
