Kutz J Walter, Verma Sunil, Tan Hongying Tina, Lo William W M, Slattery William H, Friedman Rick A
House Ear Institute, Los Angeles, California, USA.
Laryngoscope. 2007 May;117(5):848-53. doi: 10.1097/MLG.0b013e3180337da6.
Chondroblastoma is a rare tumor accounting for 1% of primary bone tumors. Chondroblastoma involving the skull base is exceedingly rare with approximately 60 cases reported. We reviewed our experience with chondroblastoma of the skull base with an emphasis on current lateral skull base approaches and long-term tumor control.
A retrospective case review at a tertiary neurotology private practice group was performed over a 20-year period. Five patients were identified with skull base chondroblastoma. All patients underwent surgical intervention, and success of surgery was determined by disease-free status at last follow-up. Mean follow-up time was 5.8 years.
Two patients underwent gross tumor removal as primary therapy. One patient underwent partial tumor removal at an outside institution, and follow-up magnetic resonance imaging demonstrated rapid growth of residual tumor. This patient was successfully treated with gross total removal of residual tumor with an infratemporal craniotomy approach. Near total tumor removal was performed in two patients because of intimate involvement of vital structures. At last follow-up, no patient had radiographic evidence of tumor recurrence. There were no significant postoperative complications.
Gross total or near total resection of skull base chondroblastomas through lateral skull base approaches results in long-term tumor control and low complication rates.
软骨母细胞瘤是一种罕见的肿瘤,占原发性骨肿瘤的1%。累及颅底的软骨母细胞瘤极为罕见,据报道约有60例。我们回顾了我们治疗颅底软骨母细胞瘤的经验,重点是当前的侧颅底入路和长期肿瘤控制情况。
在一个三级神经耳科私人执业组进行了为期20年的回顾性病例研究。确定了5例颅底软骨母细胞瘤患者。所有患者均接受了手术干预,手术的成功与否通过最后一次随访时的无病状态来确定。平均随访时间为5.8年。
2例患者接受了肿瘤全切作为初始治疗。1例患者在外部机构接受了部分肿瘤切除,随访磁共振成像显示残余肿瘤迅速生长。该患者通过颞下开颅入路成功接受了残余肿瘤全切治疗。2例患者因重要结构紧密受累而进行了近全切。在最后一次随访时,没有患者有肿瘤复发的影像学证据。没有明显的术后并发症。
通过侧颅底入路对颅底软骨母细胞瘤进行全切或近全切可实现长期肿瘤控制且并发症发生率低。