Carlson Andrew P, Yonas Howard, Olson Garth T, Reichard Kaaren K, Medina-Flores Rafael
Department of Neurological Surgery, University of New Mexico, Albuquerque, New Mexico.
Skull Base Rep. 2011 May;1(1):65-70. doi: 10.1055/s-0031-1275638. Epub 2011 Mar 25.
The case of a 51-year-old man with a large temporal mass is presented. The mass eroded the floor of the middle fossa medially to the sphenoid sinus. A combined approach with neurosurgery and otolaryngology was performed to achieve maximal resection of the mass. Pathology was typical for chondroblastoma: a rare, benign but locally invasive chondroid tumor. Genetic testing revealed a translocation of (2;5) (q33;q13). This is a unique genetic mutation in all chondroid tumors to our knowledge. The diagnostic utility or role of this mutation in the pathobiology of this tumor remains to be determined.
本文介绍了一名51岁男性患有巨大颞部肿物的病例。该肿物向内侵蚀中颅窝底至蝶窦。采用神经外科和耳鼻喉科联合手术方法，以实现肿物的最大程度切除。病理检查结果为典型的软骨母细胞瘤：一种罕见的、良性但具有局部侵袭性的软骨样肿瘤。基因检测显示存在(2;5)(q33;q13)易位。据我们所知，这是所有软骨样肿瘤中一种独特的基因突变。这种突变在该肿瘤病理生物学中的诊断效用或作用仍有待确定。
