Chamot Stéphane R, Depeursinge Christian
Microvision and Microdiagnostics Group, Advanced Photonics Laboratory, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
Minim Invasive Ther Allied Technol. 2007;16(2):101-8. doi: 10.1080/13645700701267022.
Endoluminal microscopy and spectroscopy could significantly improve the efficiency of clinical endoscopic examination by allowing in-situ detection, staging and grading of potentially cancerous lesions. Indeed, high-end optical microscopy techniques such as confocal, coherence-gated and single-/multi-photon microscopy today deliver optical histology information and spectrally/spatially resolved measurements of tissue reflectance allow grading and staging of precancerous/cancerous lesions. Owing to the brisk development of MEMS technologies, miniaturization requirements satisfying the dimension requirements for endoscope integration have been met within the last decade and the present paper will report on the current and future development of MEMS-based endoscopes for optical diagnosis.
腔内显微镜检查和光谱学可以通过对潜在癌性病变进行原位检测、分期和分级，显著提高临床内镜检查的效率。事实上，如今诸如共聚焦、相干门控和单/多光子显微镜等高端光学显微镜技术能够提供光学组织学信息，并且对组织反射率进行光谱/空间分辨测量可实现癌前/癌性病变的分级和分期。由于微机电系统（MEMS）技术的蓬勃发展，在过去十年中已满足了符合内窥镜集成尺寸要求的小型化需求，本文将报道基于MEMS的光学诊断内窥镜的当前和未来发展情况。
