[肾毒性血清诱导的肾炎大鼠肾脏中的脂质过氧化及白蛋白过载诱导的蛋白尿]

[Lipid peroxidation in the kidneys of rats with nephritis induced by nephrotoxic serum and proteinuria induced by albumin overload].

作者信息

Nikiforova N V, Kirpatovskiĭ V I, Perepechkina N P, Sevriukov E A

出版信息

Biull Eksp Biol Med. 1991 Sep;112(9):237-40.

Abstract

Lipid peroxidation (LPO) stimulated by ascorbate was studied in renal cortex of 20 rats with nephrotoxic nephritis (NTN) and of 9 rats with proteinuria induced by a 3-day course of i. p. injections of the human serum albumin. At the early stages of NTN (0.5 h. and 3 h.) LPO activities were of the same values as in control rats. A small decrease in renal cortex LPO was found on the 4-th day of NTN when nephrotic syndrome has been developed. A significant reduction in LPO activity was observed on the 16-th day of NTN characterized by a more pronounced nephrotic syndrome. LPO activity in renal cortex of the rats with albumin overload proteinuria was also reduced. An inhibitory effect of proteinuria on LPO activity in kidney is discussed.

摘要

在20只患有肾毒性肾炎（NTN）的大鼠以及9只通过腹腔注射人血清白蛋白3天诱导出蛋白尿的大鼠的肾皮质中，研究了抗坏血酸刺激的脂质过氧化（LPO）情况。在NTN的早期阶段（0.5小时和3小时），LPO活性与对照大鼠的值相同。在NTN第4天出现肾病综合征时，发现肾皮质LPO略有下降。在NTN第16天，肾病综合征更为明显，观察到LPO活性显著降低。白蛋白超负荷蛋白尿大鼠肾皮质中的LPO活性也降低。讨论了蛋白尿对肾脏LPO活性的抑制作用。