Mahía J, Bernal A, Puerto A
Psicobiología, Universidad de Granada, Campus de Cartuja, Granada 18071, Spain.
Behav Brain Res. 2007 Jul 19;181(1):147-52. doi: 10.1016/j.bbr.2007.03.026. Epub 2007 Mar 30.
Individual lesions of the caudal (E1) or rostral (E2) ventral tuberomammillary nuclei induced hyperphagia in Wistar rats. The aim of the present study was to examine the additive or united effects of combined lesions of E1+E2 in food intake. E1+E2 lesions produced an immediate, potent and permanent hyperphagic response that was greater than that observed in groups with individual lesions (E1 or E2) during the 22-day observation period. Furthermore, at the end of this period (Days 17/22), the combined lesions induced a greater increase in body weight compared with groups with individual lesions. As previously reported, polydipsia is also induced by lesions of the ventral tuberomammillary subnuclei. However, in this case, responses of the individual polydipsic groups did not differ from those found in the E1+E2 ventral tuberomammillary group. These results are interpreted in terms of the hypothalamic systems involved in food and water intake.
尾侧（E1）或吻侧（E2）腹侧乳头体核的单个损伤可导致Wistar大鼠食欲亢进。本研究的目的是研究E1 + E2联合损伤对食物摄入量的累加或联合作用。E1 + E2损伤产生了即时、强烈且持久的食欲亢进反应，在22天的观察期内，该反应比单个损伤组（E1或E2）观察到的反应更强烈。此外，在该时期结束时（第17/22天），与单个损伤组相比，联合损伤导致体重增加更多。如先前报道，腹侧乳头体亚核的损伤也会引起烦渴。然而，在这种情况下，单个烦渴组的反应与E1 + E2腹侧乳头体组的反应没有差异。这些结果是根据参与食物和水摄入的下丘脑系统来解释的。
