Rudzki Piotr J, Buś Katarzyna, Ksycińska Hanna, Kobylińska Kamila
Pharmaceutical Research Institute, Department of Pharmacology, 8 Rydygiera Street, 01-793 Warsaw, Poland.
J Pharm Biomed Anal. 2007 Jun 28;44(2):356-67. doi: 10.1016/j.jpba.2007.03.018. Epub 2007 Mar 24.
Gas and liquid chromatography-mass spectrometry (GC-MS, LC-MS) methods for the determination of angiotensin-converting enzyme inhibitors (ACEIs) and their metabolites in biological material have been reviewed. Since 1980s those hyphenated techniques have been applied to quantitate ACE inhibitors and the dynamic increase in the number of relevant publications can be observed in recent years. Although most of the methods available in the literature were analyses of plasma or serum, assays of blood and urine were also included. Additionally, sample pretreatment methods, separation conditions and ionization modes were overviewed. Some information on chemical structures, cis-trans izomerization and stability of compounds in question was also included. Most of the reported methods were successfully applied to the pharmacokinetic studies in humans.
用于测定生物材料中血管紧张素转换酶抑制剂（ACEIs）及其代谢物的气相色谱 - 质谱联用（GC-MS）和液相色谱 - 质谱联用（LC-MS）方法已被综述。自20世纪80年代以来，这些联用技术已被用于定量ACE抑制剂，并且近年来可以观察到相关出版物数量的动态增长。尽管文献中可用的大多数方法是对血浆或血清的分析，但也包括血液和尿液的检测。此外，还概述了样品预处理方法、分离条件和电离模式。还包括了有关所讨论化合物的化学结构、顺反异构化和稳定性的一些信息。大多数报道的方法已成功应用于人体药代动力学研究。
