Lbx1在后脑体感和内脏感觉中继神经元的命运决定中作为一个选择基因发挥作用。
Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.
作者信息
Sieber Martin A, Storm Robert, Martinez-de-la-Torre Margaret, Müller Thomas, Wende Hagen, Reuter Katja, Vasyutina Elena, Birchmeier Carmen
机构信息
Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
出版信息
J Neurosci. 2007 May 2;27(18):4902-9. doi: 10.1523/JNEUROSCI.0717-07.2007.
Abstract
Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.
摘要
后脑中有不同类型的中继神经元处理躯体感觉或内脏感觉信息。目前尚不清楚神经元如何在这两种命运之间做出选择。我们在此表明，同源框基因Lbx1对于赋予后脑中继神经元躯体感觉命运至关重要。在Lbx1突变小鼠中，内脏感觉中继神经元得以特化，代价是躯体感觉中继神经元。因此，Lbx1的表达区分了中继神经元的躯体感觉或内脏感觉命运。
相似文献
1
Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.Lbx1在后脑体感和内脏感觉中继神经元的命运决定中作为一个选择基因发挥作用。
J Neurosci. 2007 May 2;27(18):4902-9. doi: 10.1523/JNEUROSCI.0717-07.2007.
2
The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.同源结构域因子lbx1区分了脊髓背侧神经元分化的两个主要程序。
Neuron. 2002 May 16;34(4):551-62. doi: 10.1016/s0896-6273(02)00689-x.
3
A BMP-mediated transcriptional cascade involving Cash1 and Tlx-3 specifies first-order relay sensory neurons in the developing hindbrain.一种涉及Cash1和Tlx-3的骨形态发生蛋白（BMP）介导的转录级联反应，决定了发育中后脑的一级中继感觉神经元。
Mech Dev. 2005 Jul;122(7-8):900-13. doi: 10.1016/j.mod.2005.04.004.
4
The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei.bHLH转录因子Olig3标记后脑的背侧神经上皮，对脑干核的发育至关重要。
Development. 2009 Jan;136(2):295-305. doi: 10.1242/dev.027193. Epub 2008 Dec 15.
5
Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei.Ptf1a的缺失导致脑干中广泛的细胞命运错误指定，影响躯体感觉和内脏感觉核的发育。
J Neurosci. 2016 Mar 2;36(9):2691-710. doi: 10.1523/JNEUROSCI.2526-15.2016.
6
Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes.Lbx1和Tlx3在决定γ-氨基丁酸能与谷氨酸能递质表型方面起着相反的开关作用。
Nat Neurosci. 2005 Nov;8(11):1510-5. doi: 10.1038/nn1569. Epub 2005 Oct 23.
7
Contribution of Hox genes to the diversity of the hindbrain sensory system.Hox基因对后脑感觉系统多样性的贡献。
Development. 2004 Mar;131(6):1259-66. doi: 10.1242/dev.01029. Epub 2004 Feb 11.
8
Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord.Lbx1基因决定了脊髓背侧的体感联合中间神经元。
Neuron. 2002 May 16;34(4):535-49. doi: 10.1016/s0896-6273(02)00690-6.
9
The homeobox gene Lbx1 specifies a subpopulation of cardiac neural crest necessary for normal heart development.同源框基因Lbx1决定了正常心脏发育所必需的心脏神经嵴亚群。
Circ Res. 2003 Jan 10;92(1):73-80. doi: 10.1161/01.res.0000050587.76563.a5.
10
Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map.小鼠面部躯体感觉图谱依赖Hoxa2和菱脑节的发育。
Science. 2006 Sep 8;313(5792):1408-13. doi: 10.1126/science.1130042. Epub 2006 Aug 10.
引用本文的文献
1
A genetically defined pontine nucleus essential for ingestion in mice.一种对小鼠摄食至关重要的基因定义的脑桥核。
Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2411174122. doi: 10.1073/pnas.2411174122. Epub 2025 Jul 15.
2
Two parallel lineage-committed progenitors contribute to the developing brain.两个平行的谱系定向祖细胞参与发育中的大脑形成。
bioRxiv. 2025 Jul 5:2025.07.02.662771. doi: 10.1101/2025.07.02.662771.
3
Direct specification of lymphatic endothelium from mesenchymal progenitors.从间充质祖细胞直接定向分化为淋巴管内皮细胞。
Nat Cardiovasc Res. 2025 Jan;4(1):45-63. doi: 10.1038/s44161-024-00570-5. Epub 2025 Jan 2.
4
The alteration of LBX1 expression is associated with changes in parameters related to energy metabolism in mice.LBX1 表达的改变与小鼠能量代谢相关参数的变化有关。
PLoS One. 2024 Aug 7;19(8):e0308445. doi: 10.1371/journal.pone.0308445. eCollection 2024.
5
Genetic identification of medullary neurons underlying congenital hypoventilation.先天性通气不足相关延髓神经元的遗传学鉴定。
Sci Adv. 2024 Jun 21;10(25):eadj0720. doi: 10.1126/sciadv.adj0720. Epub 2024 Jun 19.
6
The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders.脊髓触觉加工改变的发育时间预测了自闭症谱系障碍的遗传小鼠模型中的行为变化。
Nat Neurosci. 2024 Mar;27(3):484-496. doi: 10.1038/s41593-023-01552-9. Epub 2024 Jan 17.
7
Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia.Prdm12在发育中的躯体感觉神经节中抑制内脏神经元决定因子Phox2a/b的表达。
iScience. 2023 Oct 31;26(12):108364. doi: 10.1016/j.isci.2023.108364. eCollection 2023 Dec 15.
8
Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons.Brn3a 控制着发育中脊髓背角神经元的胞体定位和轴突延伸模式。
PLoS One. 2023 Sep 21;18(9):e0285295. doi: 10.1371/journal.pone.0285295. eCollection 2023.
9
Endogenous μ-opioid-Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice.内源性μ-阿片肽-神经肽Y Y1受体协同作用可减轻小鼠术后慢性疼痛。
PNAS Nexus. 2023 Aug 14;2(8):pgad261. doi: 10.1093/pnasnexus/pgad261. eCollection 2023 Aug.
10
A new Hoxb8FlpO mouse line for intersectional approaches to dissect developmentally defined adult sensorimotor circuits.一种用于交叉方法剖析发育定义的成年感觉运动回路的新型Hoxb8FlpO小鼠品系。
Front Mol Neurosci. 2023 Aug 1;16:1176823. doi: 10.3389/fnmol.2023.1176823. eCollection 2023.
本文引用的文献
1
Delays in neuronal differentiation in Mash1/Ascl1 mutants.Mash1/Ascl1突变体中神经元分化的延迟。
Dev Biol. 2006 Jul 1;295(1):67-75. doi: 10.1016/j.ydbio.2006.03.008. Epub 2006 May 4.
2
Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps.脑干蜗神经核复合体的组装通过交叉和减法基因命运图谱得以揭示。
Neuron. 2006 Apr 20;50(2):205-18. doi: 10.1016/j.neuron.2006.03.014.
3
Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6.后脑菱唇由由Pax6分配的离散祖细胞群组成。
Neuron. 2005 Dec 22;48(6):933-47. doi: 10.1016/j.neuron.2005.11.031.
4
Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum.Math1表达重新定义了菱唇衍生物，并揭示了脑干和小脑中的新谱系。
Neuron. 2005 Oct 6;48(1):31-43. doi: 10.1016/j.neuron.2005.08.024.
5
Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors.Math1在小脑菱唇神经祖细胞的时间离散池中表达。
Neuron. 2005 Oct 6;48(1):17-24. doi: 10.1016/j.neuron.2005.08.028.
6
CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells.CXCR4与Gab1协同作用，以控制迁移性肌肉祖细胞的发育。
Genes Dev. 2005 Sep 15;19(18):2187-98. doi: 10.1101/gad.346205.
7
Compartments and their boundaries in vertebrate brain development.脊椎动物脑发育中的分区及其边界
Nat Rev Neurosci. 2005 Jul;6(7):553-64. doi: 10.1038/nrn1702.
8
A developmental switch in the response of DRG neurons to ETS transcription factor signaling.背根神经节神经元对ETS转录因子信号反应的发育性转变。
PLoS Biol. 2005 May;3(5):e159. doi: 10.1371/journal.pbio.0030159. Epub 2005 Apr 26.
9
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.Tlx3和Tlx1是有丝分裂后决定谷氨酸能而非γ-氨基丁酸能细胞命运的选择基因。
Nat Neurosci. 2004 May;7(5):510-7. doi: 10.1038/nn1221. Epub 2004 Apr 4.
10
Contribution of Hox genes to the diversity of the hindbrain sensory system.Hox基因对后脑感觉系统多样性的贡献。
Development. 2004 Mar;131(6):1259-66. doi: 10.1242/dev.01029. Epub 2004 Feb 11.
Zotero 插件