Chapple C R, Hampson S J, Turner-Warwick R T, Worth P H
Department of Urology, Middlesex Hospital, London.
Br J Urol. 1991 Nov;68(5):483-6. doi: 10.1111/j.1464-410x.1991.tb15390.x.
A series of 24 patients underwent 27 transtrigonal phenol injections for the treatment of bladder instability. Only 2 of 18 patients with detrusor instability and 2 of 6 with detrusor hyperreflexia continued to derive benefit from the procedure 6 months after it was carried out. Serious complications attributable to phenol were seen in 2 patients in this series and in a further 4 patients referred for complications resulting from this therapy in other centres. These results and a review of the literature lead us to suggest that transvesical phenol injection should not be used except in the hyper-reflexic bladder when no alternative treatment is possible. Particular care should be exercised in patients who have undergone extensive prior surgery or radiotherapy.
