Kriebel Martin, Müller Frank, Hollemann Thomas
NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Reutlingen, Germany.
Dev Dyn. 2007 Jun;236(6):1526-34. doi: 10.1002/dvdy.21170.
The transcriptional coactivater and tyrosine phosphatase eyes absent (eya) is vital for eye development in Drosophila. We identified a vertebrate member of the Eya family, Xeya3, which is expressed in the anterior neural plate, including the eye field. Overexpression of wild-type Xeya3 or of a phosphatase-negative version of Xeya3 creates massive enlargements of brain and retinal tissues, mainly caused by overproliferation of neural precursor cells. On the other hand, suppression of Xeya3 function induces local apoptosis within the sensorial layer of the anterior neuroectoderm. Thus, Xeya3 is key factor for the formation and size control of brain and eyes in vertebrates.
转录共激活因子及酪氨酸磷酸酶无眼（eya）对果蝇的眼睛发育至关重要。我们鉴定出了Eya家族的一个脊椎动物成员Xeya3，它在前神经板包括眼区中表达。野生型Xeya3或Xeya3的磷酸酶阴性版本的过表达会导致脑和视网膜组织大量增大，这主要是由神经前体细胞过度增殖引起的。另一方面，Xeya3功能的抑制会在前神经外胚层的感觉层内诱导局部凋亡。因此，Xeya3是脊椎动物脑和眼睛形成及大小控制的关键因子。
