糖原合成酶激酶3在葡萄糖稳态及胰岛素抵抗发生发展中的作用。
The role of GSK3 in glucose homeostasis and the development of insulin resistance.
作者信息
Lee Jongsoon, Kim Myung-Sunny
机构信息
Joslin Diabetes Center, Harvard Medical School, Boston, USA.
出版信息
Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S49-57. doi: 10.1016/j.diabres.2007.01.033. Epub 2007 May 2.
GSK3 has been implicated in the development of insulin resistance, primarily based on its role in regulation of glycogen synthesis. However, GSK3 is involved in many other important signaling cascades which may regulate glucose homeostasis and the development of insulin resistance. In addition, GSK3 is composed of two isoforms, GSK3alpha and beta, which do not completely share their physiological roles, and this raises a possibility that GSK3alpha and beta may function differently in glucose homeostasis. In this review, we will give an overview to examine potential mechanisms for the roles of GSK3 in the development of insulin resistance.
糖原合成激酶3（GSK3）主要因其在糖原合成调节中的作用而被认为与胰岛素抵抗的发生有关。然而，GSK3还参与许多其他重要的信号级联反应，这些反应可能调节葡萄糖稳态及胰岛素抵抗的发生。此外，GSK3由两种亚型，即GSK3α和GSK3β组成，它们并不完全共享其生理作用，这就增加了GSK3α和GSK3β在葡萄糖稳态中可能发挥不同作用的可能性。在本综述中，我们将概述探讨GSK3在胰岛素抵抗发生中作用的潜在机制。
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