Marquis Jean-Philippe, Audet Marie-Claude, Doré François Y, Goulet Sonia
Ecole de Psychologie, Université Laval, Québec, Canada.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1108-12. doi: 10.1016/j.pnpbp.2007.03.017. Epub 2007 Apr 1.
The cognitive effects of subchronic phencyclidine administration in rats are still unsettled in the literature. Possible causes of discrepancies are different drug treatment regimens and task parameters. The current experiment tested whether variations in procedures of the delayed T-maze alternation task result in performance differences following identical PCP treatments. Sixteen rats were trained on a continuous version of the T-maze task where they alternated between successive free-choice runs. Another sixteen were trained on a discrete trials version where each trial started with a forced run followed by a free choice test. After training, half of the rats submitted to each task version were treated daily for 14 days with i.p. injections of PCP (10 mg/kg) and the remaining half received a saline solution. At 48 h after the last injection, the subjects were tested for 10 days in their respective task version. Results showed that rats treated with PCP were impaired relative to controls in the continuous alternation task whereas performance of PCP and Saline groups did not differ in the discrete trials version. Cognitive control from prefrontal cortex and/or striatal response-related processes could have been damaged by PCP exposure. The systematic study of differences in tasks parameters may help reconcile discordant findings on PCP's functional outcomes.
亚慢性给予大鼠苯环利定的认知效应在文献中仍未定论。结果存在差异的可能原因是不同的药物治疗方案和任务参数。当前实验测试了在相同的苯环利定治疗后，延迟T迷宫交替任务程序的变化是否会导致行为表现的差异。16只大鼠在T迷宫任务的连续版本中接受训练，它们在连续的自由选择奔跑之间交替。另外16只大鼠在离散试验版本中接受训练，每个试验开始时是强制奔跑，随后是自由选择测试。训练后，接受每种任务版本的大鼠中有一半每天腹腔注射苯环利定（10mg/kg），持续14天，其余一半接受生理盐水溶液。在最后一次注射后48小时，对受试者在各自的任务版本中进行了10天的测试。结果表明，在连续交替任务中，接受苯环利定治疗的大鼠相对于对照组表现受损，而在离散试验版本中，苯环利定组和生理盐水组的表现没有差异。苯环利定暴露可能损害了前额叶皮层和/或纹状体反应相关过程的认知控制。对任务参数差异的系统研究可能有助于调和关于苯环利定功能结果的不一致发现。
