Suhrer Stefan J, Gruber Markus, Sippl Manfred J
Center of Applied Molecular Engineering, Department of Bioinformatics, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W411-5. doi: 10.1093/nar/gkm264. Epub 2007 May 3.
QSCOP is a quantitative structural classification of proteins which distinguishes itself from other classifications by two essential properties: (i) QSCOP is concurrent with the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank and (ii) QSCOP covers the widely used SCOP classification with layers of quantitative structural information. The QSCOP-BLAST web server presented here combines the BLAST sequence search engine with QSCOP to retrieve, for a given query sequence, all structural information currently available. The resulting search engine is reliable in terms of the quality of results obtained, and it is efficient in that results are displayed instantaneously. The hierarchical organization of QSCOP is used to control the redundancy and diversity of the retrieved hits with the benefit that the often cumbersome and difficult interpretation of search results is an intuitive and straightforward exercise. We demonstrate the use of QSCOP-BLAST by example. The server is accessible at http://qscop-blast.services.came.sbg.ac.at/
QSCOP是一种蛋白质定量结构分类方法，它通过两个基本特性与其他分类方法区分开来：（i）QSCOP与结构生物信息学研究合作实验室（RCSB）蛋白质数据库同步，（ii）QSCOP通过定量结构信息层覆盖广泛使用的SCOP分类。这里展示的QSCOP-BLAST网络服务器将BLAST序列搜索引擎与QSCOP相结合，以便为给定的查询序列检索当前可用的所有结构信息。所得的搜索引擎在获得的结果质量方面是可靠的，并且在结果即时显示方面是高效的。QSCOP的层次结构用于控制检索到的命中结果的冗余性和多样性，其好处是通常繁琐且难以解释的搜索结果变得直观且易于操作。我们通过示例演示了QSCOP-BLAST的使用。该服务器可通过http://qscop-blast.services.came.sbg.ac.at/访问。
