Köksal Nilgün, Harmanci Ramazan, Cetinkaya Merih, Hacimustafaoğlu Mustafa
Department of Pediatrics, Uludağ University, Faculty of Medicine, Bursa, Turkey.
Turk J Pediatr. 2007 Jan-Mar;49(1):21-9.
We aimed to investigate the role of procalcitonin in the diagnosis and follow-up of neonatal sepsis, and to compare it with C-reactive protein (CRP) in this context. Between April and October 2002, a total of 67 neonates were randomly recruited into the study and were divided into four groups as: those with highly probable sepsis (group 1), probable sepsis (group 2), possible sepsis (group 3), and no sepsis (group 4; controls). When the initial procalcitonin levels of the groups were compared, the results were statistically significant (p < 0.05) except for the comparison between groups 3 and 4 (p > 0.05). When the initial CRP levels were compared between the groups, the levels measured in groups 1 and 2 were significantly higher than the levels measured in groups 3 and 4 (p < 0.05). In addition, the decreasing levels in procalcitonin were statistically more significant than the decreasing levels in CRP in showing the response to antibiotic treatment (p < 0.01 and p < 0.05, respectively). In conclusion, serum procalcitonin levels seemed to be superior to serum CRP levels in terms of early diagnosis of neonatal sepsis, in detecting the severity of the illness, and in evaluation of the response to antibiotic treatment.
我们旨在研究降钙素原在新生儿败血症诊断及随访中的作用，并在此背景下将其与C反应蛋白（CRP）进行比较。2002年4月至10月期间，共有67例新生儿被随机纳入本研究，并分为四组：极有可能患败血症组（第1组）、可能患败血症组（第2组）、可能患败血症组（第3组）和无败血症组（第4组；对照组）。比较各组降钙素原初始水平时，除第3组和第4组之间的比较外（p>0.05），结果具有统计学意义（p<0.05）。比较各组CRP初始水平时，第1组和第2组测得的水平显著高于第3组和第4组测得的水平（p<0.05）。此外，在显示对抗生素治疗的反应方面，降钙素原水平的下降在统计学上比CRP水平的下降更显著（分别为p<0.01和p<0.05）。总之，血清降钙素原水平在新生儿败血症的早期诊断、检测疾病严重程度以及评估对抗生素治疗的反应方面似乎优于血清CRP水平。
