Kan Toshiyuki, Kita Yoichi, Morohashi Yuichi, Tominari Yusuke, Hosoda Shinnosuke, Tomita Taisuke, Natsugari Hideaki, Iwatsubo Takeshi, Fukuyama Tohru
School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, Japan.
Org Lett. 2007 May 24;9(11):2055-8. doi: 10.1021/ol070376i. Epub 2007 May 5.
Convenient synthesis of a variety of photoaffinity probes was accomplished by utilizing our Ns strategy and novel resin. The synthetic probes were evaluated via the labeling ability with the preseniline 1 C-terminal fragments, which was identified as a therapeutic target for Alzheimer's disease.
通过使用我们的Ns策略和新型树脂，实现了多种光亲和探针的便捷合成。通过与早老素1 C末端片段的标记能力对合成探针进行了评估，早老素1 C末端片段被确定为阿尔茨海默病的治疗靶点。
