光亲和探针的便捷合成及其标记能力评估。
Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.
作者信息
Kan Toshiyuki, Kita Yoichi, Morohashi Yuichi, Tominari Yusuke, Hosoda Shinnosuke, Tomita Taisuke, Natsugari Hideaki, Iwatsubo Takeshi, Fukuyama Tohru
机构信息
School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, Japan.
出版信息
Org Lett. 2007 May 24;9(11):2055-8. doi: 10.1021/ol070376i. Epub 2007 May 5.
PMID:17480083
Abstract
Convenient synthesis of a variety of photoaffinity probes was accomplished by utilizing our Ns strategy and novel resin. The synthetic probes were evaluated via the labeling ability with the preseniline 1 C-terminal fragments, which was identified as a therapeutic target for Alzheimer's disease.
摘要
通过使用我们的Ns策略和新型树脂，实现了多种光亲和探针的便捷合成。通过与早老素1 C末端片段的标记能力对合成探针进行了评估，早老素1 C末端片段被确定为阿尔茨海默病的治疗靶点。
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